This study on validating a novel NGS-based BCR::ABL1 kinase domain mutation detection assay is highly relevant to the Molecular Streaming Corps (MSC) mission. It demonstrates the power of advanced molecular characterization techniques in improving disease diagnostics and treatment outcomes, aligning with MSC's goal of comprehensive molecular analysis. The use of RNA as a starting material and the ability to detect mutations with high sensitivity showcase the potential for nanopore-based technologies to further enhance such assays. This work exemplifies the type of molecular-level biomedical research that could benefit from the universal molecular streaming capabilities MSC aims to develop, potentially enabling real-time, high-throughput mutation detection in complex biological samples.